Predicting protein complexes from protein-protein interaction data is becoming a fundamental problem in computational biology. The identification and characterization of protein complexes implicated are crucial to the understanding of the molecular events under normal and abnormal physiological conditions.
This app detects protein complex using weighted clustering coefficient. For more details you may refer to the paper: http://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-14-163.
The app can be used to detect dense sub-networks in any kind of networks such as gene network or social network, etc.
If you use this application please cite the paper:
Zaki NM., Dmitry D. and Berengueres J. (2013), Protein Complex Detection using Interaction Reliability Assessment and Weighted Clustering Coefficient. BMC Bioinformatics, 14:163.
