Categories: cancer data analysis, data integration, functional analysis, integrated analysis, literature mining, network inference, Pathway acitivity analysis, prognostic network module, signaling, systems biology, Topology

*There are two mechanisms that maintain the length of telomeres in healthy and cancerous tissues: telomerase-dependent and alternative (ALT) mechanisms. This project is aimed at fostering research on telomere maintenance mechanisms (TMM).* - We provide Telomerase and ALT TMM pathways that we’ve curated based on literature and gene expression data. - We’ve created this app for assessment of TMM activity from gene expression data. - You may use these pathways and our app to assess which TMM mechanism is active in your samples, if you’ve got gene expression data for them. - Most importantly, we believe that many researchers may contribute their knowledge or data to improve these pathways and to deepen current understanding of molecular mechanisms leading to TMM activation. Please, note that TMM depends on [http://apps.cytoscape.org/apps/psfc PSFC] app.

Authors:

• Lilit Nersisyan (Bioinformatics Group, Institute of Molecular Biology NAS, Armenia)
• Arsen Arakelyan (Bioinformatics Group, Institute of Molecular Biology NAS, Armenia)