NeDRex

Finds drug repurposing candidates and disease modules. Builds custom heterogeneous molecular networks
NeDRex is the first generically applicable integrated platform for network-based disease module discovery and drug repurposing. It is build of three main components: a knowledgebase ([https://nedrex.net/tutorial/intro.html#nedrexdb NeDRexDB]), a Cytoscape app ([https://nedrex.net/tutorial/ NeDRexApp]), and an API ([https://api.nedrex.net/ NeDRexAPI]). NeDRexApp provides implementations of diverse network algorithms, such as Multi-Steiner Trees ([https://www.nature.com/articles/s41467-020-17189-2 MuST]), [https://www.nature.com/articles/s41467-020-17189-2 TrustRank], Biclustering Constrained by Networks ([https://academic.oup.com/bioinformatics/advance-article-abstract/doi/10.1093/bioinformatics/btaa1076/6050718 BiCoN]), and Disease Module Detection ([https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004120 DIAMOnD]). All algorithms except for BiCoN (uses gene expression data) require a list of user-selected genes (referred to as seeds) as starting point. Seeds can be all or a subset of the genes associated with the disease, so-called disease genes, or genes contained in disease modules. Moreover, NeDRex allows researchers to leverage their *expert knowledge* for discovering drug repurposing candidates via network medicine methods. Our platform can also be used to identify disease modules and possibly repurposable drugs for any newly discovered disease such as COVID-19.

1.0.0

Works with Cytoscape 3.6


CYTOSCAPE 3

Version 1.0.0

Released 8 Jul 2021

Works with Cytoscape 3.6

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