Enables simultaneous comparison of interaction network of two species. protein domain information can be visualized.
Categories: network comparison
Protein interaction networks contain a wealth of biological information, but their large size often hinders cross-organism comparisons. OrthoNets is a Cytoscape plugin that displays PPI networks from two organisms simultaneously, highlighting orthology relationships and aggregating several types of biomedical annotations. OrthoNets also allows PPI networks derived from experiments to be overlaid on networks extracted from public databases, supporting the identification and verification of new interactors. Any newly identified PPIs can be validated by checking whether their orthologs interact in another organism.
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