Pathway activity is estimated by its capacity to propagate an amount of signal from the input to the outputs. PSFC estimates the signal flow propagation on pathways based on the pathway topology and node input data.
With PSFC you can:
* Calculate the signal flow propagation based on gene expression, gene methylation, protein activity, and any other type of data.
* Estimate the activity state of the pathway and its component nodes: compare these states in health and disease.
* Apply custom algorithms to model signal propagation on the pathway.
* Visualize flow propagation in Cytoscape.
We have opened a PSFC discussion group at https://groups.google.com/forum/#!forum/psfc-discussion-group. Please, post your questions and comments to the group, or e-mail your quesionts and thoughts.
Nersisyan L, Johnson G, Riel-Mehan M et al. PSFC: a Pathway Signal Flow Calculator App for Cytoscape [v1; ref status: awaiting peer review, http://f1000r.es/5k3] F1000Research 2015, 4:480 (doi: [http://f1000research.com/articles/4-480/v1 10.12688/f1000research.6706.1])